DJ Khaled praises the Wegovy pill in a star-studded Super Bowl LX ad with Kenan Thompson, John C. Reilly and Ana Gasteyer. The upcoming commercial brings together humor, celebrity energy, and an important health message as the music mogul leads a lively campaign spotlighting a new option for weight management.
A Big Announcement With Big Personalities
DJ Khaled is turning up the volume on wellness as he joins a lineup of well-known faces in a 90-second Super Bowl LX commercial debuting during the Feb. 8 broadcast. The ad introduces a new daily pill version of the GLP-1 weight management medication Wegovy, designed to support adults living with obesity when combined with healthy lifestyle changes.
The commercial opens with comedian and longtime Saturday Night Live star Kenan Thompson standing atop a water tower in a scenic field, making a dramatic announcement: Wegovy is now available in pill form. From below, Khaled enthusiastically reinforces the message, highlighting that the medication works alongside diet and exercise to help people lose weight and maintain their progress.
Thompson then adds a relatable twist, asking viewers to consider whether they’d take a pill if it helped unlock other healthy possibilities.
Humor, Music and Wishful Thinking
Set to Skee-Lo’s classic hit “I Wish,” the ad leans into playful fantasy. Actor John C. Reilly jokes about wanting a pill to master parallel parking, while Khaled imagines becoming a professional wrestler. Actress Danielle Brooks dreams of rescuing more kittens with ease, passing one off to Danny Trejo, and Ana Gasteyer humorously wishes for a pill that would make people less judgmental about different weight-loss journeys.
The lighthearted storytelling aims to challenge the perception that medical weight-loss support is “the easy way out,” instead emphasizing that real results still require commitment to healthier habits.
A New Option From Novo Nordisk
The commercial marks the first national campaign for Novo Nordisk’s once-daily Wegovy 25 mg tablet. The message focuses on giving adults with obesity another medically guided tool to support long-term health when combined with balanced nutrition and regular physical activity.
Khaled’s Personal Motivation
In a statement, Khaled shared why the partnership resonated with him. He spoke about the frustration many people feel when they stay disciplined with workouts and clean eating but still struggle to see results. As a father and husband, he said his goal is to be at his best for his family — and having additional options like the Wegovy pill can make a meaningful difference for those working toward better health.
When and Where to Watch
Super Bowl LX will take place at Levi’s Stadium in Santa Clara, California, airing on NBC with coverage beginning at 1 p.m. ET. Alongside the game’s on-field action, viewers can expect this celebrity-packed commercial to be one of the most talked-about moments of the broadcast.
DJ Khaled praises the Wegovy pill in a star-studded Super Bowl LX ad with Kenan Thompson, John C. Reilly and Ana Gasteyer. The campaign blends entertainment with awareness, delivering a message that achieving health goals often takes dedication — and sometimes, the right support.
